Enhanced Replication of Human Cytomegalovirus in Human Fibroblasts Treated with Dexamethasone

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Enhanced replication of human cytomegalovirus in human fibroblasts treated with dexamethasone.

The effect of glucocorticoid hormones on the replication of human cytomegalovirus (HCMV) was studied in human embryonic lung (HEL) cells. Treatment of cells with pharmacological concentrations of adrenal glucocorticoids such as dexamethasone enhanced HCMV replication; treatment with oestrogenic or androgenic hormones did not do so. In dexamethasone-treated HEL cells there was an approximately t...

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Growth characteristics of cytomegalovirus in human fibroblasts with demonstration of protein synthesis early in viral replication.

In high-multiplicity infection of human fibroblasts, human cytomegalovirus of WI-38 human diploid cells produced early cell rounding 6 to 24 h after inoculation. This early cell rounding was caused only by inoculation with infectious virions. Inhibitors of protein synthesis, but not DNA inhibitors, prevented this cytopathic effect. Apparently, a new protein is synthesized in infected fibroblast...

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ژورنال

عنوان ژورنال: Journal of General Virology

سال: 1984

ISSN: 0022-1317,1465-2099

DOI: 10.1099/0022-1317-65-10-1759